Scientists have tried to reprogram various origins of primary cells into human induced pluripotent stem cells (hiPSCs). Every\nsomatic cell can theoretically become a hiPSC and give rise to targeted cells of the human body. However, there have been\ndebates on the controversy about the differentiation propensity according to the origin of primary cells. We reprogrammed\nhiPSCs from four different types of primary cells such as dermal fibroblasts (DF, n = 3), peripheral blood mononuclear cells\n(PBMC, n = 3), cord blood mononuclear cells (CBMC, n = 3), and osteoarthritis fibroblast-like synoviocytes (OAFLS, n = 3).\nEstablished hiPSCs were differentiated into chondrogenic pellets. All told, cartilage-specific markers tended to express more by\nthe order of CBMC> DF >PBMC > FLS. Origin of primary cells may influence the reprogramming and differentiation\nthereafter. In the context of chondrogenic propensity, CBMC-derived hiPSCs can be a fairly good candidate cell source for\ncartilage regeneration. The differentiation of hiPSCs into chondrocytes may help develop ââ?¬Å?cartilage in a dishââ?¬Â in the future. Also,\nthe ideal cell source of hiPSC for chondrogenesis may contribute to future application as well.
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